PROCESS FOR MAKING AN EP4 ANTAGONIST

PROCESS FOR MAKING AN EP4 ANTAGONIST

The present disclosure provides the methods for making 4-[4-cyano-2-({[(2'R,4S)-6-(isopropylcarbamoyl)-2,3-dihydrospiro[chromene-4,1'-cyclopropan]-2'-yl]carbonyl}amino)phenyl]butanoic acid. The present disclosure also generally relates to intermediates useful in the said methods. La p...

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Bibliographische Detailangaben
Hauptverfasser: CHO, Patricia Y, SAGAWA, Naoya, YU, Miao, COOMBS, John Ryan, GUO, Xuelei, STEINHARDT, Sarah Evelyn, WISNIEWSKI, Steven R, BEUTNER, Gregory Louis, GUERRERO, Carlos A, HAY, Michael Bryan, ARIHARA, Ryoichi
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present disclosure provides the methods for making 4-[4-cyano-2-({[(2'R,4S)-6-(isopropylcarbamoyl)-2,3-dihydrospiro[chromene-4,1'-cyclopropan]-2'-yl]carbonyl}amino)phenyl]butanoic acid. The present disclosure also generally relates to intermediates useful in the said methods. La présente divulgation concerne les procédés de production d'acide 4-[4-cyano-2-({[(2'R,4S)-6-(isopropylcarbamoyl)-2,3-dihydrospiro[chromène-4,1'-cyclopropan]-2'-yl]carbonyl}amino)phényl]butanoïque. La présente divulgation concerne également d'une manière générale des intermédiaires utiles dans lesdits procédés.