DNAZYMES TARGETING CELL WALL SYNTHESIS ENZYMES AND USES THEREOF

Provided herein are compositions and methods comprising a DNAzyme targeting a transcript encoding a cell wall synthesis enzyme, for use in reducing an amount of a biofilm in a subject with a bacterial infection; increasing or enhancing antibiotic susceptibility in a subject with a bacterial infectio...

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Bibliographische Detailangaben
Hauptverfasser:	LEVY-ZAMIR, Adva, OSHRI, Roni, BRACHELET, Ido, ROSENBERGER, Alexander, KOLODKIN-GAL, Ilana, GILLIS, Ella, ABU-HOROWITZ, Almogit
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are compositions and methods comprising a DNAzyme targeting a transcript encoding a cell wall synthesis enzyme, for use in reducing an amount of a biofilm in a subject with a bacterial infection; increasing or enhancing antibiotic susceptibility in a subject with a bacterial infection; and inhibiting bacterial growth in a subject with a bacterial infection. L'invention concerne des compositions et des procédés comprenant une DNAzyme ciblant un transcrit codant pour une enzyme de synthèse de paroi cellulaire, à utiliser pour réduire une quantité d'un biofilm chez un sujet atteint d'une infection bactérienne ; augmenter ou améliorer la sensibilité aux antibiotiques chez un sujet atteint d'une infection bactérienne ; et inhiber la croissance bactérienne chez un sujet atteint d'une infection bactérienne.