ANTI-TIGIT ANTIBODY AND USE THEREOF

An antibody specifically binding to TIGIT or an antigen-binding fragment thereof can effectively block the binding of TIGIT to a ligand thereof and release the inhibitory effect of the ligand of TIGIT on a downstream signal of TIGIT. The present invention further relates to a composition containing...

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Bibliographische Detailangaben
Hauptverfasser:	DAI, Shuang, SCHUTZ, Kevin, XU, Yingda, HEMMERLEIN, Megan, HUANG, Weifeng, ZHAI, Tianhang, BUKOWSKI, Jon
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	An antibody specifically binding to TIGIT or an antigen-binding fragment thereof can effectively block the binding of TIGIT to a ligand thereof and release the inhibitory effect of the ligand of TIGIT on a downstream signal of TIGIT. The present invention further relates to a composition containing the antibody or the antigen-binding fragment thereof, a nucleic acid coding the antibody or the antigen-binding fragment thereof, a host cell containing the nucleic acid, and a related use. In addition, the present invention relates to treatment and diagnosis uses of the antibody or the antigen-binding fragment thereof. L'invention concerne un anticorps se liant de manière spécifique à TIGIT ou un fragment de liaison à l'antigène de celui-ci qui peut bloquer de manière efficace la liaison de TIGIT à son ligand et libérer l'effet inhibiteur du ligand de TIGIT sur un signal aval de TIGIT. La présente invention concerne en outre une composition contenant l'anticorps ou le fragment de liaison à l'antigène de celui-ci,