COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITING

The disclosure provides methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making and using modified nucleic acid donor templates for highly efficient and precise gene editing, such as gene editing in immune cells via homology-directed rep...

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Bibliographische Detailangaben
Hauptverfasser:	SONTHEIMER, Erik Joseph, MELLO, Craig Cameron, CHEN, Zexiang, GHANTA, Krishna Sumanth, WATTS, Jonathan Kenneth
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The disclosure provides methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making and using modified nucleic acid donor templates for highly efficient and precise gene editing, such as gene editing in immune cells via homology-directed repair (HDR) or homology-independent targeted integration (HITI). L'invention concerne des procédés et des compositions pour l'édition de gènes. En particulier, l'invention concerne des compositions et des procédés de fabrication et d'utilisation de modèles donneurs d'acide nucléique modifiés pour une édition génique hautement efficace et précise, telle que l'édition de gène dans des cellules immunitaires.