COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE

Provided are new compositions and methods useful for the treatment, prevention, and potential cure of Alzheimer's Disease by disrupting the genomic locus of IL1LR1 gene including rs1921622 and/or other 574 sST2-associated genomic sites and/or 3' -UTR of sST2 gene/transcript. L'inventi...

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Hauptverfasser: WONG, Hiu Yi, IP, Fanny Chui Fun, DUAN, Yangyang, ZHOU, Xiaopu, OUYANG, Li, JIANG, Yuanbing, FU, Kit Yu, IP, Nancy Yuk Yu
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Provided are new compositions and methods useful for the treatment, prevention, and potential cure of Alzheimer's Disease by disrupting the genomic locus of IL1LR1 gene including rs1921622 and/or other 574 sST2-associated genomic sites and/or 3' -UTR of sST2 gene/transcript. L'invention concerne de nouvelles compositions et des méthodes utiles pour le traitement, la prévention et le remède potentiel de la maladie d'Alzheimer en perturbant le locus génomique du gène IL1LR1 comprenant rs1921622 et/ou d'autres sites génomiques associés à 574 sST2 et/ou à 3 '-UTR du gène/transcrit sST2.