COMPOSITIONS AND METHODS FOR INHIBITION OF RAS

COMPOSITIONS AND METHODS FOR INHIBITION OF RAS

Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation)...

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Bibliographische Detailangaben
Hauptverfasser: XU, Rui, YANG, Yue, WALLACE, Eli, ZHANG, Zuhui, LIAO, Tao, LIGHTSTONE, Felice, BRASSARD, Christopher John, CHAN, Albert Hay Wah, WANG, Bin, BISIGNANO, Paola, MACIAG, Anna Elzbieta, TURNER, David Michael, SIMANSHU, Dhirendra Kumar
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof. L'invention concerne des composés, ou des sels, des esters, des tautomères, des promédicaments, des formes zwitterioniques ou des stéréo-isomères de ceux-ci, ainsi que des compositions pharmaceutiques les comprenant. L'invention concerne également des procédés d'utilisation de ceux-ci dans la modulation (par exemple, l'inhibition) de KRAS (par exemple, KRAS ayant une mutation G12C) et le traitement de maladies ou de troubles tels que des cancers chez des sujets en ayant besoin.