SOLID FORMS AND FORMULATIONS OF AN INHIBITOR OF TAM AND C-MET KINASES

SOLID FORMS AND FORMULATIONS OF AN INHIBITOR OF TAM AND C-MET KINASES

This invention relates to solid forms of (R)-N-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)phenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, amorphous solid dispersions of (R)-N-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)ami...

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Bibliographische Detailangaben
Hauptverfasser: COWDREY, Connor James, KRISHNASWAMI, Sriram, GOODWIN, Aaron Keith, BERCHIELLI, Alfred, HARIHARAN, Subramanian, CLARK, Wesley Dewitt
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:This invention relates to solid forms of (R)-N-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)phenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, amorphous solid dispersions of (R)-N-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)phenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, pharmaceutical compositions comprising such amorphous dispersions, and to methods of using such solid forms and pharmaceutical compositions in the treatment of proliferative diseases such as cancer. L'invention concerne des formes solides de (R)-N-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)phényl)-3-(4-fluorophényl)-1-isopropyl-2,4-dioxo-1,2,3,4-tétrahydropyrimidine-5-carboxamide, des dispersions solides amorphes de (R)-N-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)phényl)-3-(4-fluorophényl)-1-isopropyl-2,4-dioxo-1,2,3,4-tétrahydropyrimidine-5-carboxamide, des compositions pharmaceutiques comprenant ces dispersions amorphes, et des procédés d'utilisation de ces formes solides et de ces compositions pharmaceutiques dans le traitement de maladies prolifératives telles que le cancer.