BISPECIFIC ANTIBODY TARGETING PD-L1 AND 4-1BB

Provided in the present application is a bispecific antibody targeting PD-L1 and 4-1BB. The bispecific antibody cannot only block the binding of PD-1 and PD-L1, but can also activate a human 4-1BB signal pathway and stimulate the activation of T cells, and can be used for an immunopotentiator or an...

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Bibliographische Detailangaben
Hauptverfasser:	ZENG, Xiaoli, CHENG, Liansheng, WANG, Mengli, WEI, Juanjuan, ZHANG, Dayan, WU, Lingling, DAI, Xuejing, LIU, Wenting, ZHOU, Weiming
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided in the present application is a bispecific antibody targeting PD-L1 and 4-1BB. The bispecific antibody cannot only block the binding of PD-1 and PD-L1, but can also activate a human 4-1BB signal pathway and stimulate the activation of T cells, and can be used for an immunopotentiator or an immunomodulator of autoimmune diseases mediated by T cells. La présente invention concerne un anticorps bispécifique ciblant PD-L1 et 4-1BB. L'anticorps bispécifique ne peut bloquer que la liaison de PD-1 et PD-L1, mais peut également activer une voie de signalisation 4-1BB humaine et stimuler l'activation de lymphocytes T, et peut être utilisé pour un immunopotentialisateur ou un immunomodulateur de maladies auto-immunes médiées par les lymphocytes T. 本申请提供了靶向PD-L1和4-1BB的双特异性抗体。该双特异性抗体既能阻断PD-1与PD-L1的结合，又能激活人4-1BB信号通路，刺激T细胞活化，其能够用于免疫增强物，或T细胞介导的自身免疫疾病的免疫调节物。