NOVEL RNA THERAPEUTICS AND USES THEREOF

The present disclosure relates to novel RNAi agents designed to decrease the expression of ANGPTL8 in the liver, where the RNAi agents comprise delivery moieties conjugated to oligonucleotides optionally via a linker. The RNAi agents are useful in the treatment of diseases involving the regulation o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	BELLINGER, Melissa, EGGEN, MariJean, BEYER, Thomas, CHENG, Christine, LACKNER, Gregory, MILES, Rebecca, WANG, Jibo
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates to novel RNAi agents designed to decrease the expression of ANGPTL8 in the liver, where the RNAi agents comprise delivery moieties conjugated to oligonucleotides optionally via a linker. The RNAi agents are useful in the treatment of diseases involving the regulation of ANGPTL8 expression. La présente invention concerne de nouveaux agents ARNi conçus pour diminuer l'expression d'ANGPTL8 dans le foie, les agents ARNi comprenant des fractions d'administration conjuguées à des oligonucléotides éventuellement par l'intermédiaire d'un lieur. Les agents ARNi sont utiles dans le traitement de maladies impliquant la régulation de l'expression d'ANGPTL8.