A CRYSTALLINE POTASSIUM SALT OF 1-ETHYL- N -((1,2,3,5,6,7-HEXAHYDRO- S -INDACEN-4-YL)CARBAMOYL)PIPERIDINE-4 -SULFONAMIDE

A CRYSTALLINE POTASSIUM SALT OF 1-ETHYL- N -((1,2,3,5,6,7-HEXAHYDRO- S -INDACEN-4-YL)CARBAMOYL)PIPERIDINE-4 -SULFONAMIDE

The present invention relates to a crystalline potassium salt of 1-ethyl-N-((1,2,3,5,6,7- hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and to hydrates, solvates and polymorphic forms thereof. The present invention further relates to pharmaceutical compositions comprising this compound...

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Bibliographische Detailangaben
Hauptverfasser: WERMELINGER, Marc, HIDBER, Pirmin, ENKELMANN, Dennis Dimo
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to a crystalline potassium salt of 1-ethyl-N-((1,2,3,5,6,7- hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and to hydrates, solvates and polymorphic forms thereof. The present invention further relates to pharmaceutical compositions comprising this compound and the use of this compound in the treatment and prevention of medical diseases, disorders and conditions, most especially by NLRP3 inhibition. La présente invention concerne un sel de potassium cristallin de 1-éthyl-N-((1,2,3,5-hexahydro-s-indacèn-4-yl))carbamoyl)pipéridine-4-sulfonamide et ses hydrates, solvates et formes polymorphes. La présente invention concerne en outre des compositions pharmaceutiques comprenant ce composé et l'utilisation de ce composé dans le traitement et la prévention de maladies, troubles et états de santé, plus particulièrement par inhibition de NLRP3.