SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS

Provided herein are SOS1 protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of an SOS1-mediated disorder, disease, or condition. Formula (I) L...

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Bibliographische Detailangaben
Hauptverfasser:	PAPA, Patrick, TORRES, Eduardo, HECHT, David Aaron, ERDMAN, Paul E, FUNG, Leah M, CHOURASIA, Aparajita Hoskote, LAM, Imelda, SCHOOLMEESTERS, Angela, CHAN, Kyle W.H
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are SOS1 protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of an SOS1-mediated disorder, disease, or condition. Formula (I) La présente invention concerne des agents de dégradation de protéine SOS1, par exemple, un composé de formule (I), et des compositions pharmaceutiques de ceux-ci. L'invention concerne également des procédés d'utilisation de ceux-ci pour traiter, prévenir ou améliorer un ou plusieurs symptômes d'un trouble, d'une maladie ou d'un état médié par SOS1. Formule (I)