SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Disclosed are compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are defined herein. Also disclosed are methods of using such compounds as inhibitors of LRRK2, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating ne...

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Bibliographische Detailangaben
Hauptverfasser:	PETIT, Frédéric, DEPRETS, Stéphanie, MACOR, John, BERNARDELLI, Patrick, TERRIER, Corinne, DUBOIS, Laurent, BIANCIOTTO, Marc
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are defined herein. Also disclosed are methods of using such compounds as inhibitors of LRRK2, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating neurodegenerative diseases such as Parkinson's disease. L'invention concerne des composés de formule (I), ou un sel pharmaceutiquement acceptable de ceux-ci, dans laquelle R1 et R2 sont tels que définis dans la description. L'invention concerne également des procédés d'utilisation de tels composés en tant qu'inhibiteurs de LRRK2, et des compositions pharmaceutiques comprenant de tels composés. Ces composés sont utiles dans le traitement de maladies neurodégénératives telles que la maladie de Parkinson.