METHODS OF USE OF ANTI-SORTILIN ANTIBODIES

The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured or humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Sortilin protein, e.g., human Sortilin or mammalian So...

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Bibliographische Detailangaben
Hauptverfasser:	LIAO, Yijie, WANG, Whedy, MANGAL, Brian C, JACKSON, Sam, WARD, Michael F, HUANG, Julie Y, PAUL, Robert, SIDDIQUI, Omer Rizwan, YEH, Felix Leejia
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured or humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, in treating and/or delaying progression of a disease or injury in an individual in need thereof. La présente divulgation concerne de manière générale l'utilisation de compositions qui comprennent des anticorps, par exemple, des anticorps monoclonaux, chimériques, à maturation d'affinité, humanisés, des fragments d'anticorps, etc., qui se lient de manière spécifique à un ou à plusieurs épitopes dans une protéine de sortiline, par exemple, une sortiline humaine ou une sortiline mammifère, et qui présentent des caractéristiques fonctionnelles améliorées et/ou accrues, dans le traitement et/ou dans le retardement de la progression d'une maladie ou d'une lésion chez un individu qui en a besoin.