NUCLEOSIDE DERIVATIVE HAVING MULTI-TARGET KINASE INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING CANCER COMPRISING SAME

The present invention relates to a nucleoside derivative, which can be used for the prevention or treatment of cancer by inhibiting a kinase, and a pharmaceutical composition comprising same, wherein the nucleoside derivative has inhibitory activity against kinases such as NTRK1, CSNK1D, DYRK1A, DYRK1B, and FLT3, and thus, exhibits inhibitory activity against various cancer cells directly or indirectly related to the kinase, so that the nucleoside derivative can be used to prevent or treat various cancers such as lung cancer, colon cancer, breast cancer, liver cancer, stomach cancer, and prostate cancer. La présente invention concerne un dérivé de nucléoside qui peut être utilisé dans la prévention ou dans le traitement du cancer par inhibition d'une kinase, ainsi qu'une composition pharmaceutique le contenant, le dérivé de nucléoside présente une activité inhibitrice conte les kinases telles que NTRK1, CSNK1D, DYRK1A, DYRK1B et FLT3, et par conséquent il présente une activité inhibitrice contre diverses cellules cancéreuses directement ou indirectement reliées à la kinase, de sorte que le dérivé de nucléoside peut être utilisé pour prévenir ou pour traiter divers cancers tels que le cancer des poumons, le cancer du colon, le cancer du sein, le cancer du foie, le cancer de l'estomac et le cancer de la prostate. 본 발명은 인산화효소를 저해함으로써 암 예방 또는 치료에 사용될 수 있는 뉴클레오사이드 유도체 및 이를 포함하는 약학적 조성물에 관한 것으로서, 상기 뉴클레오사이드 유도체는 NTRK1, CSNK1D, DYRK1A, DYRK1B 및 FLT3와 같은 인산화효소들에 대해 저해 활성을 가지며, 이에 따라 인산화효소와 직간접적으로 연관된 다양한 암세포에 대한 저해 활성을 나타내기 때문에, 폐암, 결장암, 유방암, 간암, 위암 및 전립선암 등의 각종 암을 예방 또는 치 치료하는데 사용될 수 있다.