METHOD FOR SCREENING FOR COMPOUND FOR INHIBITING IL-33 PROTEIN AND PHARMACEUTICAL COMPOSITION FOR TREATING ALLERGIC DISEASE COMPRISING THE COMPOUND

The present invention relates to a method for screening for a compound that binds to human IL-33 protein and inhibits IL-33, a composition for inhibiting IL-33 protein, comprising a compound selected through screening, and a pharmaceutical composition for treating an allergic disease comprising same. A compound fragment that binds to IL-33, selected by using a method for screening for compound fragments that bind to IL-33 protein, according to the present invention, binds to the IL-33 protein more specifically and strongly to inhibit the IL-33 protein, and thus can be effective in treating or preventing allergic diseases, such as asthma and atopic dermatitis. La présente invention concerne un procédé de criblage d'un composé qui se lie à la protéine IL-33 humaine et inhibe l'IL-33, une composition pour inhiber la protéine IL-33, comprenant un composé sélectionné par criblage, et une composition pharmaceutique pour le traitement d'une maladie allergique le comprenant. L'invention concerne également un fragment de composé qui se lie à l'IL-33, sélectionné à l'aide d'un procédé de criblage de fragments de composé qui se lient à la protéine IL-33, selon la présente invention, se lie à la protéine IL-33 plus particulièrement et fortement pour inhiber la protéine IL-33, et peut ainsi être efficace dans le traitement ou la prévention de maladies allergiques, telles que l'asthme et la dermatite atopique. 본 발명은 인간 IL-33 단백질에 결합하여 IL-33을 저해하는 화합물을 스크리닝하는 방법, 스크리닝을 통해 선별된 화합물을 포함하는 IL-33 단백질 저해용 조성물 및 이를 포함하는 알러지성 질환 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 IL-33 단백질에 결합하는 화합물 프레그먼트를 스크리닝하는 방법을 이용하여 선별한 IL-33에 결합하는 화합물 프레그먼트는 IL-33단백질에 보다 특이적이고 강하게 결합하여 IL-33 단백질을 저해하므로 천식, 아토피 등 알러지성 질환을 치료 또는 예방하는 데 효과적이다.