SUBSTITUTED PHENYL-1H-PYRROLO[2, 3-c]PYRIDINE DERIVATIVES

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to...

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Bibliographische Detailangaben
Hauptverfasser:	DYUBANKOVA, Natalia Nikolaevna, DAI, Xuedong, NG, Alicia Tee Fuay, HULPIA, Fabian, DENG, Xiangjun, ZHANG, Zhigao, LEPRI, Susan, DARVILLE, Nicolas Freddy Jacques Bruno, PANDE, Vineet, EDWARDS, James Patrick, CAI, Wei, QUEROLLE, Olivier Alexis Georges, SUN, Zhen, DEMIN, Samuël Dominique, JOUFFROY, Matthieu, THURING, Johannes Wilhelmus J, LI, Ming, SCHEPENS, Wim Bert Griet, LIANG, Chao
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes. La présente invention concerne des agents pharmaceutiques utiles pour la thérapie et/ou la prophylaxie chez un mammifère, une composition pharmaceutique comprenant de tels composés, et leur utilisation en tant qu'inhibiteurs de l'interaction ménine/protéine MLL/protéine, utiles pour le traitement de maladies telles que le cancer, notamment mais non exclusivement la leucémie, le syndrome myélodysplasique (MDS) et des néoplasmes myéloprolifératifs (MPN); et le diabète.