TRANSAMINASE ENZYMES FOR THE TRANSAMINATION OF (1S,5R)-6,8-DIOXABICYCLO[3.2.1]OCTAN-4-ONE

The present disclosure provides transaminase enzymes having improved properties and are capable of reducing (1S,5R)-6,8-dioxabicyclo[3.2.1]octan-4-one with high selectivity. Also provided are polynucleotides encoding the transaminase enzymes, host cells capable of expressing the transaminase enzymes...

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Bibliographische Detailangaben
Hauptverfasser:	PAN, Weilan, MURPHY, Grant, VERMA, Deeptak, CHEUNG-LEE, Wai Ling, MCINTOSH, John, PRIER, Christopher, CAMACHO SOTO, Karla, HO, Hsing-I
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides transaminase enzymes having improved properties and are capable of reducing (1S,5R)-6,8-dioxabicyclo[3.2.1]octan-4-one with high selectivity. Also provided are polynucleotides encoding the transaminase enzymes, host cells capable of expressing the transaminase enzymes, and methods of using the transaminase enzymes to synthesize (1S,4R,5R)-6,8-dioxabicyclo[3.2.1]octan-4-amine. La présente invention concerne des enzymes transaminases ayant des propriétés améliorées et sont aptes à réduire le (1S,5R)-6,8-dioxabicyclo[3.2.1]octan-4-one avec une sélectivité élevée. L'invention concerne également des polynucléotides codant pour les enzymes transaminases, des cellules hôtes aptes à exprimer les enzymes transaminases, ainsi que des procédés d'utilisation des enzymes transaminases pour synthétiser une (1S,4R,5R)-6,8-dioxabicyclo[3.2.1]octan-4-amine.