A METHOD AND SYSTEM FOR INTEGRATED AND CONTINUOUS VIRAL FILTRATION, CONCENTRATION AND BUFFER EXCHANGE

A method and system for integrated and continuous viral filtration and biological product concentration, including an initial purification system coupled to a final purification system. The initial purification system includes a viral reduction filtration (VRF) skid, while the final purification sys...

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Bibliographische Detailangaben
Hauptverfasser:	GODFREY, Scott, KHOURI, Joelle, ZHU, Min, IKON, Nikita, OROZCO, Raquel, CAPRON, Charles
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A method and system for integrated and continuous viral filtration and biological product concentration, including an initial purification system coupled to a final purification system. The initial purification system includes a viral reduction filtration (VRF) skid, while the final purification system includes a single-pass tangential filtration- diafiltration (SPTFF-DF) skid. Procédé et système intégrés et continus de filtration virale et de concentration de produits biologiques, comprenant un système de purification initiale couplé à un système de purification finale. Le système de purification initial comprend un patin de filtration par réduction virale (VRF), tandis que le système de purification final comprend un patin de filtration-diafiltration tangentielle à passage unique (SPTFF-DF).