CHIMERIC ANTIGEN RECEPTOR TARGETING GPRC5D, AND USE THEREOF

Provided are a chimeric antigen receptor targeting G protein-coupled receptor C5 family subtype D (GPRC5D), and a preparation method and use therefor, especially the use thereof as an anti-cancer drug. The chimeric antigen receptor targeting GPRC5D includes extracellular antigen-binding domain. The...

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Bibliographische Detailangaben
Hauptverfasser:	DU, Bing, LIU, Mingyao, XI, Zaixi, ZHANG, Jiqin, ZHAO, Ruihua
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	Provided are a chimeric antigen receptor targeting G protein-coupled receptor C5 family subtype D (GPRC5D), and a preparation method and use therefor, especially the use thereof as an anti-cancer drug. The chimeric antigen receptor targeting GPRC5D includes extracellular antigen-binding domain. The extracellular antigen-binding domain includes a GPRC5D antibody light chain variable region and a GPRC5D antibody heavy chain variable region. A single-chain antibody (ScFv) that recognizes the tumor surface antigen GPRC5D is bound to a T cell activation domain and expressed in T cells, so as to recognize and bind the tumor surface antigen, induce T cell activation, secrete cytokines to kill tumor cells, which has a significant effect in the treatment of B lymphoma and acute lymphoblastic leukemia. L'invention concerne un récepteur antigénique chimérique ciblant le sous-type D de la famille C5 du récepteur couplé à la protéine G (GPRC5D), son procédé de préparation et son utilisation, en particulier son utilisation