A STABLE PHARMACEUTICAL COMPOSITION COMPRISING SELEXIPAG

The present invention relates to a stable solid pharmaceutical composition comprising a) Selexipag, b) D-mannitol having a specific surface area of 1.2 m2/g or more, and c) a starch in an amount of 50% to 80% by weight based on the total weight of the solid composition. The invention further relates...

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Bibliographische Detailangaben
Hauptverfasser:	KUMAR, Ayush, DUDE, Udaya Kumar, ESKI, Volkan, ALMAREDDY, Srinivasa Reddy, PATIL, Ravindra
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a stable solid pharmaceutical composition comprising a) Selexipag, b) D-mannitol having a specific surface area of 1.2 m2/g or more, and c) a starch in an amount of 50% to 80% by weight based on the total weight of the solid composition. The invention further relates to a process for the preparation of such pharmaceutical composition and use of said pharmaceutical composition as medicament in the treatment of pulmonary arterial hypertension. La présente invention concerne une composition pharmaceutique solide stable comprenant a) Sélexipag, b) D-mannitol ayant une surface spécifique de 1.2 m2/g ou plus, et c) un amidon en une quantité de 50 % à 80 % en poids sur la base du poids total de la composition solide. L'invention concerne en outre un procédé de préparation d'une telle composition pharmaceutique et l'utilisation de ladite composition pharmaceutique en tant que médicament dans le traitement de l'hypertension artérielle pulmonaire.