SUBSTITUTED SPIRO DERIVATIVES

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, myelodysplastic syndrome (MD...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	COLOMBEL, Hélène France Solange, DAI, Xuedong, KRAMER, Carsten Sven, FANG, Lichao, XU, Yanping, PILATTE, Isabelle Noëlle Constance, PONCELET, Virginie Sophie, DENG, Xiangjun, LIU, Yingtao, PANDE, Vineet, CAI, Wei, QUEROLLE, Olivier Alexis Georges, THURING, Johannes Wilhelmus J, QIN, Luoheng, WU, Jianping, ANGIBAUD, Patrick René, LIU, Lianzhu, LI, Ming
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, myelodysplastic syndrome (MDS) and diabetes. La présente invention concerne des agents pharmaceutiques utiles pour la thérapie et/ou la prophylaxie chez un mammifère, une composition pharmaceutique comprenant de tels composés, et leur utilisation en tant qu'inhibiteurs d'interactions de protéine/protéine MLL/ménine, utiles pour le traitement de maladies telles que le cancer, le syndrome myélodysplasique (MDS) et le diabète.