ENZYME VARIANTS AND USES THEREOF

The present disclosure relates generally to a polypeptide having mono-(2-hydroxyethyl) terephthalate hydrolase (MHETase) activity, more specifically to a polypeptide comprising an amino acid sequence that (i) has at least 70% sequence identity to SEQ ID NO:1 and (ii) differs from SEQ ID NO:1 by an a...

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Bibliographische Detailangaben
Hauptverfasser:	VONGSOUTHI, Vanessa, SAUNDERS, Jake Wesley, JACKSON, Colin John, SPENCE, Matthew, DAMRY, Adam Michael
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY GENERAL PROCESSES OF COMPOUNDING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC MACROMOLECULAR COMPOUNDS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS THEIR PREPARATION OR CHEMICAL WORKING-UP VINEGAR WINE WORKING-UP
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Beschreibung
Zusammenfassung:	The present disclosure relates generally to a polypeptide having mono-(2-hydroxyethyl) terephthalate hydrolase (MHETase) activity, more specifically to a polypeptide comprising an amino acid sequence that (i) has at least 70% sequence identity to SEQ ID NO:1 and (ii) differs from SEQ ID NO:1 by an amino acid substitution at one or more positions selected from the group consisting of positions that correspond to amino acid positions 156 to 396, 398 to 410 and 425 to 603 of SEQ ID NO:1. La présente divulgation concerne de manière générale un polypeptide ayant une activité de mono-(2-hydroxyéthyl)téréphtalate hydrolase (MHETase), plus particulièrement un polypeptide comprenant une séquence d'acides aminés ayant (i) une identité de séquence d'au moins 70 % avec la SEQ ID NO: 1 et (ii) diffèrant de SEQ ID NO: 1 par une substitution d'acide aminé à une ou plusieurs positions choisies dans le groupe constitué par les positions correspondant aux positions d'acides aminés 156 à 396, 398 à 410 et 425 à 603 de SEQ ID NO: 1.