COMBINATION THERAPY BY USING AKR1C3-ACTIVATED COMPOUND WITH IMMUNE CHECKPOINT INHIBITOR

A pharmaceutical composition, including a compound l-(3-(3-N,N- dimethylaminocarbonyl)phenoxyl-4-mtrophenyl)-l-ethyl-N,N'- bis(ethylene)phosphoramidate and at least one therapeutic agent including a chemotherapeutic agent or biological agent, and its medical use are provided. Une composition ph...

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Bibliographische Detailangaben
Hauptverfasser:	LI, Wan-Fen, LAI, Ming-Tain, CHEN, Lu-Tzu, WANG, Chun-Chung
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	A pharmaceutical composition, including a compound l-(3-(3-N,N- dimethylaminocarbonyl)phenoxyl-4-mtrophenyl)-l-ethyl-N,N'- bis(ethylene)phosphoramidate and at least one therapeutic agent including a chemotherapeutic agent or biological agent, and its medical use are provided. Une composition pharmaceutique, comprenant un composé l-(3-(3-N,N-diméthylaminocarbonyl) phénoxyl-4-mtrophényl)-l-éthyl-N,N'-bis(éthylène)phosphoramidate et au moins un agent thérapeutique comprenant un agent chimiothérapeutique ou un agent biologique, ainsi que son utilisation médicale.