1H-PYRAZOLE DERIVATIVES AS SIGMA LIGANDS

The present invention relates to new 1H-pyrazole derivatives of formula (I) as sigma ligands having a great affinity for sigma receptors, especially the sigma-1 receptor (σ1) and/or sigma-2 receptor (σ2), as well as to the process for the preparation thereof, to compositions comprising them, and to...

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Bibliographische Detailangaben
Hauptverfasser:	ALMANSA-ROSALES, Carmen, LLORENTE-FERNÁNDEZ, Ana Virginia, GARCÍA-LÓPEZ, Mónica, DÍAZ-FERNÁNDEZ, Jose Luís, CHRISTMANN, Ute
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to new 1H-pyrazole derivatives of formula (I) as sigma ligands having a great affinity for sigma receptors, especially the sigma-1 receptor (σ1) and/or sigma-2 receptor (σ2), as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments. Formula (I). La présente invention concerne de nouveaux dérivés de 1H-pyrazole de formule (I) utilisés en tant que ligands sigma ayant une grande affinité pour les récepteurs sigma, en particulier le récepteur sigma-1 (σ1) et/ou un récepteur sigma-2 (σ2), ainsi que leur procédé de préparation, des compositions les comprenant, et leur utilisation en tant que médicaments. Formule (I).