3H,4H,5H,6H,7H-PYRIMIDO[4,5-B][1,4]OXAZINE-4,6-DIONE DERIVATIVES AS TRPA1 INHIBITORS
The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPAl. Also provided are pharmaceutical c...
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| creator | BINDER, Florian Paul Christian FLECK, Martin Thomas |
| description | The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPAl. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
La présente invention concerne certains dérivés de 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione qui sont des inhibiteurs de récepteur à potentiel de récepteur transitoire ankyrine 1 (TRPA1), et sont par conséquent utiles pour le traitement de maladies pouvant être traitées par inhibition de TRPAl. L'invention concerne également des compositions pharmaceutiques les contenant, et des procédés de préparation desdits composés. |
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La présente invention concerne certains dérivés de 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione qui sont des inhibiteurs de récepteur à potentiel de récepteur transitoire ankyrine 1 (TRPA1), et sont par conséquent utiles pour le traitement de maladies pouvant être traitées par inhibition de TRPAl. L'invention concerne également des compositions pharmaceutiques les contenant, et des procédés de préparation desdits composés.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221020&DB=EPODOC&CC=WO&NR=2022219012A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221020&DB=EPODOC&CC=WO&NR=2022219012A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BINDER, Florian Paul Christian</creatorcontrib><creatorcontrib>FLECK, Martin Thomas</creatorcontrib><title>3H,4H,5H,6H,7H-PYRIMIDO[4,5-B][1,4]OXAZINE-4,6-DIONE DERIVATIVES AS TRPA1 INHIBITORS</title><description>The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPAl. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
La présente invention concerne certains dérivés de 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione qui sont des inhibiteurs de récepteur à potentiel de récepteur transitoire ankyrine 1 (TRPA1), et sont par conséquent utiles pour le traitement de maladies pouvant être traitées par inhibition de TRPAl. L'invention concerne également des compositions pharmaceutiques les contenant, et des procédés de préparation desdits composés.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrsKwjAUANAuDqL-Q8D1Bpo0rTimNnLvYFOSUB-llCJxEi3U_8fFD3A6y1kmIUNQCDlCgbBD3lwdnaiynYKcl30nQPX2om9UG66g4BXZ2rDKOGp1oNZ4pj0LrtGCUY1UUrDOr5PFY3zOcfNzlWyPJhyQx-k9xHka7_EVP8PZylRKKfapkFpk_60vWHAwDw</recordid><startdate>20221020</startdate><enddate>20221020</enddate><creator>BINDER, Florian Paul Christian</creator><creator>FLECK, Martin Thomas</creator><scope>EVB</scope></search><sort><creationdate>20221020</creationdate><title>3H,4H,5H,6H,7H-PYRIMIDO[4,5-B][1,4]OXAZINE-4,6-DIONE DERIVATIVES AS TRPA1 INHIBITORS</title><author>BINDER, Florian Paul Christian ; FLECK, Martin Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022219012A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BINDER, Florian Paul Christian</creatorcontrib><creatorcontrib>FLECK, Martin Thomas</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BINDER, Florian Paul Christian</au><au>FLECK, Martin Thomas</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>3H,4H,5H,6H,7H-PYRIMIDO[4,5-B][1,4]OXAZINE-4,6-DIONE DERIVATIVES AS TRPA1 INHIBITORS</title><date>2022-10-20</date><risdate>2022</risdate><abstract>The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPAl. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
La présente invention concerne certains dérivés de 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione qui sont des inhibiteurs de récepteur à potentiel de récepteur transitoire ankyrine 1 (TRPA1), et sont par conséquent utiles pour le traitement de maladies pouvant être traitées par inhibition de TRPAl. L'invention concerne également des compositions pharmaceutiques les contenant, et des procédés de préparation desdits composés.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 3H,4H,5H,6H,7H-PYRIMIDO[4,5-B][1,4]OXAZINE-4,6-DIONE DERIVATIVES AS TRPA1 INHIBITORS |
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