3H,4H,5H,6H,7H-PYRIMIDO[4,5-B][1,4]OXAZINE-4,6-DIONE DERIVATIVES AS TRPA1 INHIBITORS

3H,4H,5H,6H,7H-PYRIMIDO[4,5-B][1,4]OXAZINE-4,6-DIONE DERIVATIVES AS TRPA1 INHIBITORS

The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPAl. Also provided are pharmaceutical c...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BINDER, Florian Paul Christian, FLECK, Martin Thomas
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPAl. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds. La présente invention concerne certains dérivés de 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione qui sont des inhibiteurs de récepteur à potentiel de récepteur transitoire ankyrine 1 (TRPA1), et sont par conséquent utiles pour le traitement de maladies pouvant être traitées par inhibition de TRPAl. L'invention concerne également des compositions pharmaceutiques les contenant, et des procédés de préparation desdits composés.