RECOMBINANT MYCOBACTERIUM STRAIN EXPRESSING SARS-COV-2 ANTIGEN, AND VACCINE COMPOSITION INCLUDING SAME

The present invention relates to a recombinant Mycobacterium paragordonae (Mpg) strain expressing a SARS-CoV-2 antigen, and a vaccine composition including same. The recombinant Mycobacterium paragordonae strain expressing the SARS-CoV-2 antigen of the present invention can generate remarkable immun...

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Bibliographische Detailangaben
Hauptverfasser:	LEE, Moon-Su, SHIN, Ju-Yeop, JIN, Ju-Young, JEONG, Do-Hyeon, KIM, Byoung-Jun, KIM, Bum-Joon
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a recombinant Mycobacterium paragordonae (Mpg) strain expressing a SARS-CoV-2 antigen, and a vaccine composition including same. The recombinant Mycobacterium paragordonae strain expressing the SARS-CoV-2 antigen of the present invention can generate remarkable immune responses, including neutralizing antibody activity, against SARS-CoV-2 in mice. Accordingly, the recombinant Mycobacterium paragordonae strain of the present invention can be effectively used as a vaccine for preventing or treating SARS-CoV-2 infection. La présente invention concerne une souche recombinée de Mycobacterium paragordonae (Mpg) exprimant un antigène du SARS-CoV-2, et une composition de vaccin la comprenant. La souche recombinée de Mycobacterium paragordonae exprimant un antigène du SARS-CoV-2 de la présente invention peut générer des réponses immunitaires considérables, y compris une activité d'anticorps neutralisants, contre le SARS-CoV-2 chez les souris. Par conséquent, la souche recombinée de Mycobacterium paragordonae de la présente invention peut être utilisée efficacement comme vaccin pour prévenir ou traiter une infection à SARS-CoV-2. 본 발명은 본 발명은 SARS-CoV-2 항원을 발현하는 재조합 마이코박테리움 파라고르도네(Mycobacterium paragordonae, Mpg) 균주 및 이를 포함하는 백신 조성물에 관한 것이다. 본 발명의 SARS-CoV-2 항원을 발현하는 재조합 마이코박테리움 파라고르도네 균주는 마우스에서 SARS-CoV-2에 대해 중화항체능을 비롯하여 현저한 면역 반응을 생성할 수 있다. 따라서, 본 발명의 재조합 마이코박테리움 파라고르도네 균주는 SARS-CoV-2 감염을 예방하거나 치료하기 위한 백신으로 유용하게 사용될 수 있다.