TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
The disclosure provides the use of neurofilament light chain levels for selecting a subject with a mutation in the superoxide dismutase 1 (SOD1) gene for treatment with a SOD1-targeting antisense oligonucleotide or salt thereof. The disclosed methods can be used in the treatment amyotrophic lateral...
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| creator | LIU, Yingying WONG, Janice Chun Yee FRADETTE, Stephanie Melillo GRAHAM, Danielle LeeZetta SUN, Peng |
| description | The disclosure provides the use of neurofilament light chain levels for selecting a subject with a mutation in the superoxide dismutase 1 (SOD1) gene for treatment with a SOD1-targeting antisense oligonucleotide or salt thereof. The disclosed methods can be used in the treatment amyotrophic lateral sclerosis, including clinically presymptomatic amyotrophic lateral sclerosis.
La présente invention concerne l'utilisation des niveaux de chaîne légère de neurofilament pour sélectionner un sujet présentant une mutation dans le gène de la superoxyde dismutase 1 (SOD1) pour un traitement avec un oligonucléotide antisens ciblant SOD1 ou un de ses sels. Les procédés de l'invention peuvent être utilisés dans le traitement de la sclérose latérale amyotrophique, y compris la sclérose latérale amyotrophique cliniquement présymptomatique. |
| format | Patent |
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La présente invention concerne l'utilisation des niveaux de chaîne légère de neurofilament pour sélectionner un sujet présentant une mutation dans le gène de la superoxyde dismutase 1 (SOD1) pour un traitement avec un oligonucléotide antisens ciblant SOD1 ou un de ses sels. Les procédés de l'invention peuvent être utilisés dans le traitement de la sclérose latérale amyotrophique, y compris la sclérose latérale amyotrophique cliniquement présymptomatique.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221006&DB=EPODOC&CC=WO&NR=2022212459A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221006&DB=EPODOC&CC=WO&NR=2022212459A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU, Yingying</creatorcontrib><creatorcontrib>WONG, Janice Chun Yee</creatorcontrib><creatorcontrib>FRADETTE, Stephanie Melillo</creatorcontrib><creatorcontrib>GRAHAM, Danielle LeeZetta</creatorcontrib><creatorcontrib>SUN, Peng</creatorcontrib><title>TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS</title><description>The disclosure provides the use of neurofilament light chain levels for selecting a subject with a mutation in the superoxide dismutase 1 (SOD1) gene for treatment with a SOD1-targeting antisense oligonucleotide or salt thereof. The disclosed methods can be used in the treatment amyotrophic lateral sclerosis, including clinically presymptomatic amyotrophic lateral sclerosis.
La présente invention concerne l'utilisation des niveaux de chaîne légère de neurofilament pour sélectionner un sujet présentant une mutation dans le gène de la superoxyde dismutase 1 (SOD1) pour un traitement avec un oligonucléotide antisens ciblant SOD1 ou un de ses sels. Les procédés de l'invention peuvent être utilisés dans le traitement de la sclérose latérale amyotrophique, y compris la sclérose latérale amyotrophique cliniquement présymptomatique.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAKCXJ1DPF19QtR8HdTcPSN9A8J8g_w8HRW8HEMcQ1y9FEIdvZxDfIP9gzmYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBkZGRoZGJqaWjobGxKkCAABtJc8</recordid><startdate>20221006</startdate><enddate>20221006</enddate><creator>LIU, Yingying</creator><creator>WONG, Janice Chun Yee</creator><creator>FRADETTE, Stephanie Melillo</creator><creator>GRAHAM, Danielle LeeZetta</creator><creator>SUN, Peng</creator><scope>EVB</scope></search><sort><creationdate>20221006</creationdate><title>TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS</title><author>LIU, Yingying ; WONG, Janice Chun Yee ; FRADETTE, Stephanie Melillo ; GRAHAM, Danielle LeeZetta ; SUN, Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022212459A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LIU, Yingying</creatorcontrib><creatorcontrib>WONG, Janice Chun Yee</creatorcontrib><creatorcontrib>FRADETTE, Stephanie Melillo</creatorcontrib><creatorcontrib>GRAHAM, Danielle LeeZetta</creatorcontrib><creatorcontrib>SUN, Peng</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIU, Yingying</au><au>WONG, Janice Chun Yee</au><au>FRADETTE, Stephanie Melillo</au><au>GRAHAM, Danielle LeeZetta</au><au>SUN, Peng</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS</title><date>2022-10-06</date><risdate>2022</risdate><abstract>The disclosure provides the use of neurofilament light chain levels for selecting a subject with a mutation in the superoxide dismutase 1 (SOD1) gene for treatment with a SOD1-targeting antisense oligonucleotide or salt thereof. The disclosed methods can be used in the treatment amyotrophic lateral sclerosis, including clinically presymptomatic amyotrophic lateral sclerosis.
La présente invention concerne l'utilisation des niveaux de chaîne légère de neurofilament pour sélectionner un sujet présentant une mutation dans le gène de la superoxyde dismutase 1 (SOD1) pour un traitement avec un oligonucléotide antisens ciblant SOD1 ou un de ses sels. Les procédés de l'invention peuvent être utilisés dans le traitement de la sclérose latérale amyotrophique, y compris la sclérose latérale amyotrophique cliniquement présymptomatique.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS |
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