METHODS FOR DOSING AND TREATMENT WITH A COMBINATION OF A CHECKPOINT INHIBITOR THERAPY AND A CAR T CELL THERAPY

Provided herein are methods and uses of combination therapies involving a T cell therapy, e.g., a CAR T cell therapy, and a checkpoint inhibitor therapy, e.g. an anti-PD-1 antibody and/or an anti-LAG3 antibody, for treating subjects with cancers such as lymphomas, and related methods, uses, and arti...

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Hauptverfasser:	TREDE, Nikolaus Sebastian, SRIVASTAVA, Shivani, AGRAWAL, Shruti, SURYAWANSHI, Satyendra, PULHAM, Tim
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are methods and uses of combination therapies involving a T cell therapy, e.g., a CAR T cell therapy, and a checkpoint inhibitor therapy, e.g. an anti-PD-1 antibody and/or an anti-LAG3 antibody, for treating subjects with cancers such as lymphomas, and related methods, uses, and articles of manufacture. L'invention concerne des méthodes et des utilisations de polythérapies impliquant une thérapie par lymphocytes T, par exemple, une thérapie par lymphocytes CAR T, et une thérapie par inhibiteur de point de contrôle, par exemple un anticorps anti-PD-1 et/ou un anticorps anti-LAG3, pour traiter des sujets atteints de cancers tels que des lymphomes, et des méthodes, des utilisations et des articles de fabrication associés.