3'-[(2Z)-[1-(3,4-DIMETHYLPHENYL)-1,5-DIHYDRO-3-METHYL-5-OXO-4H-PYRAZOL-4-YLIDENE]HYDRAZINO]-2'-HYDROXY-[1,1'-BIPHENYL]-3-CARBOXYLIC ACID AND ITS SALTS FORMULATION

3'-[(2Z)-[1-(3,4-DIMETHYLPHENYL)-1,5-DIHYDRO-3-METHYL-5-OXO-4H-PYRAZOL-4-YLIDENE]HYDRAZINO]-2'-HYDROXY-[1,1'-BIPHENYL]-3-CARBOXYLIC ACID AND ITS SALTS FORMULATION

The present invention relates to an oral pharmaceutical formulation, suitably tablets, suitably capsules, comprising 3'-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid (INN name eltrombopag) or a pha...

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Bibliographische Detailangaben
Hauptverfasser: PATEL, Parthkumar, PATIDAR, Kanhaiyalal, ROYCE, Alan Edward, VELIP, Chandrakant, VERMA, Daya D, SHAIKH HAMID, Shaikh Mohsin, BORDAWEKAR, Mangesh Sadashiv
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The present invention relates to an oral pharmaceutical formulation, suitably tablets, suitably capsules, comprising 3'-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid (INN name eltrombopag) or a pharmaceutically acceptable salt thereof, wherein the oral pharmaceutical formulation is coated with an enteric coating. La présente invention concerne une formulation pharmaceutique orale, de façon appropriée des comprimés, de façon appropriée des gélules, comprenant du 3'-[(2Z)-[1-(3,4-diméthylphényl)-1,5-dihydro-3-méthyl-5-oxo-4H-pyrazol-4-ylidène]hydrazino]-2'-hydroxy-[1,1'-biphényl]-3-carboxylique (dénomination INN : eltrombopag) ou un sel pharmaceutiquement acceptable associé, la formulation pharmaceutique orale étant revêtue d'un enrobage entérique.