IMIDAZO[1,2-B]PYRIDAZINE BASED TRICYCLIC COMPOUNDS AS INHIBITORS OF HASPIN AND THERAPEUTIC USES THEREOF

The present invention relates to a group of compounds with a tricyclic core based on imidazo[1,2-b]pyridazine of formula (I) which are inhibitors of HASPIN, whose activity is required for the proliferation of certain tumoral cells, so the compounds of the invention are useful for the prevention and/...

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Bibliographische Detailangaben
Hauptverfasser:	BLANCO APARICIO, Carmen, PASTOR FERNÁNDEZ, Joaquín, RODRÍGUEZ ARÍSTEGUI, Sonsoles, CEBRIÁ GÓMEZ, Antonio, GÓMEZ DE LA OLIVA, Cristina Ana, ALBARRÁN SANTIÑO, María Isabel, MALUMBRES MARTÍNEZ, Marcos, GARCÍA GARCÍA, Ana Belén, MARTÍNEZ GONZÁLEZ, Sonia
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a group of compounds with a tricyclic core based on imidazo[1,2-b]pyridazine of formula (I) which are inhibitors of HASPIN, whose activity is required for the proliferation of certain tumoral cells, so the compounds of the invention are useful for the prevention and/or treatment of cancer, alone or in combination with chemotherapeutic agents. La présente invention concerne un groupe de composés ayant un noyau tricyclique à base d'imidazo[1,2-b]pyridazine de formule (I) qui sont des inhibiteurs de HASPIN, dont l'activité est requise pour la prolifération de certaines cellules tumorales, de sorte que les composés selon l'invention sont utiles pour la prévention et/ou le traitement du cancer, seuls ou en combinaison avec des agents chimiothérapeutiques.