ANTI-HER2 ANTIBODY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Provided is a non-cardiotoxic antibody drug for breast cancer treatment.　The present invention relates to an anti-HER2 antibody, or a functional fragment thereof, that binds to HER2 expressed in breast cancer cells and does not bind to HER2 expressed in myocardial cells, and a pharmaceutical composi...

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Bibliographische Detailangaben
Hauptverfasser:	MATSUURA, Katsuhisa, HORIMOTO, Yoshiya, ONO, Ken-ichiro, SASAKI, Ritsuko, AKATSUKA, Jun-ichi, SUZUKI, Kazuhiro, SHIMIZU, Tatsuya, FUJIHIRA, Haruhiko, SAITO, Mitsue, IRIMURA, Tatsuro, NAGAI DENDA, Kaori, NISHIDA, Shiyo, NOJI, Miki
Format:	Patent
Sprache:	eng ; fre ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided is a non-cardiotoxic antibody drug for breast cancer treatment.　The present invention relates to an anti-HER2 antibody, or a functional fragment thereof, that binds to HER2 expressed in breast cancer cells and does not bind to HER2 expressed in myocardial cells, and a pharmaceutical composition containing the same. L'invention concerne un médicament à base d'anticorps non cardiotoxique pour le traitement du cancer du sein.　La présente invention concerne un anticorps anti-HER2, ou un fragment fonctionnel de celui-ci, qui se lie à HER2 exprimé dans des cellules du cancer du sein et ne se lie pas à HER2 exprimé dans les cellules myocardiques, et une composition pharmaceutique le contenant. 心毒性のない乳癌治療用抗体医薬を提供する。　本発明は、乳癌細胞に発現するＨＥＲ２に結合し、心筋細胞に発現するＨＥＲ２に結合しない抗ＨＥＲ２抗体又はその機能的断片、及びこれを含有する医薬組成物に関する。