METHODS AND COMPOSITIONS FOR THE DELIVERY OF RETROVIRAL PARTICLES

The present disclosure provides methods and compositions for modifying lymphocytes, for example T cells and/or NK cells, for example in vivo. The disclosed compositions can include replication incompetent recombinant retroviral particles (RIPs), formulations thereof, and administration of RIP formul...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	KERKAR, Sidharth, KUNDU, Anirban, HENKELMAN, John R, FROST, Gregory Ian, SCHREIBER, Gregory, VIGANT, Frederic
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present disclosure provides methods and compositions for modifying lymphocytes, for example T cells and/or NK cells, for example in vivo. The disclosed compositions can include replication incompetent recombinant retroviral particles (RIPs), formulations thereof, and administration of RIP formulations to a subject. Furthermore, the compositions can include chemokines, including chemokines delivered and/or associated with RIPs. La présente invention concerne des procédés et des compositions pour modifier des lymphocytes, par exemple des lymphocytes T et/ou des cellules NK, par exemple in vivo. Les compositions divulguées peuvent inclure des particules rétrovirales recombinées incapables de se répliquer (RIP), des formulations associées, et l'administration de formulations de RIP à un sujet. En outre, les compositions peuvent inclure des chimiokines, y compris des chimiokines administrées et/ou associées à des RIP.