METHODS AND THERAPEUTIC COMBINATIONS FOR TREATING IDIOPATHIC INTRACRANIAL HYPERTENSION AND CLUSTER HEADACHES

METHODS AND THERAPEUTIC COMBINATIONS FOR TREATING IDIOPATHIC INTRACRANIAL HYPERTENSION AND CLUSTER HEADACHES

Methods and therapeutic combinations are provided for treating idiopathic intracranial hypertension (IIH) and cluster headache, comprising administering a somatostatin mimetic such as octreotide formulated for direct nose-to-brain administration, and a carbonic anhydrase inhibitor such as topiramate...

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Bibliographische Detailangaben
Hauptverfasser: BEVEC, Dorian, PRICE, Fredric, WASIEWSKI, Warren, FRANKEL, Barry
Format: Patent
Sprache:eng ; fre
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Methods and therapeutic combinations are provided for treating idiopathic intracranial hypertension (IIH) and cluster headache, comprising administering a somatostatin mimetic such as octreotide formulated for direct nose-to-brain administration, and a carbonic anhydrase inhibitor such as topiramate or acetazolamide, at a dose level and/or dosing regimen lower than effective when administered alone. L'invention concerne des méthodes et des combinaisons thérapeutiques pour le traitement de l'hypertension intracrânienne idiopathique (IIH) et de l'algie vasculaire de la face, comprenant l'administration d'un mimétique de somatostatine tel que l'octréotide formulé pour une administration directe par la voie nez-cerveau, et un inhibiteur d'anhydrase carbonique tel que le topiramate ou l'acétazolamide, à un niveau de dose et/ou à un régime de dosage inférieur à celui efficace lorsqu'est administré seul.