MATERIALS AND METHODS FOR TARGETING REGULATORY T CELLS FOR ENHANCING IMMUNE SURVEILLANCE

MATERIALS AND METHODS FOR TARGETING REGULATORY T CELLS FOR ENHANCING IMMUNE SURVEILLANCE

A molecule comprising a first means of binding to a first antigen expressed on a regulatory T (Treg) cell, and a second means capable of binding to a second antigen expressed on the Treg cell, wherein the molecule is capable of inhibiting growth or proliferation of or depleting a Treg cell. L'i...

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Bibliographische Detailangaben
Hauptverfasser: SINGH, Sanjaya, GREWAL, Lqbal, GANESAN, Rajkumar, DEES, Sundee
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A molecule comprising a first means of binding to a first antigen expressed on a regulatory T (Treg) cell, and a second means capable of binding to a second antigen expressed on the Treg cell, wherein the molecule is capable of inhibiting growth or proliferation of or depleting a Treg cell. L'invention concerne une molécule comprenant un premier moyen de liaison à un premier antigène exprimé sur un lymphocyte T régulateur (Treg) et un second moyen capable de se lier à un second antigène exprimé sur le lymphocyte Treg, la molécule étant capable d'inhiber la croissance ou la prolifération d'un lymphocyte Treg ou d'appauvrir un lymphocyte Treg.