PYRIMIDO-PYRIDONE DERIVATIVE AS SOS1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF

A pyrimido-pyridone derivative as an SOS1 inhibitor, a preparation method therefor and a use thereof. The pyrimido-pyridone derivative has a structure as shown in formula (I), and has significant effects for inhibiting an RAS signal pathway and treating and/or preventing cancers. The cancers compris...

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Hauptverfasser:	QIAO, Gang, YE, Yangliang, LU, Xiaojie, ZHENG, Suxin, ZHENG, Mingyue, XIE, Chengying
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	A pyrimido-pyridone derivative as an SOS1 inhibitor, a preparation method therefor and a use thereof. The pyrimido-pyridone derivative has a structure as shown in formula (I), and has significant effects for inhibiting an RAS signal pathway and treating and/or preventing cancers. The cancers comprise pancreatic cancer, colorectal cancer, lung cancer, hepatocellular carcinoma, renal carcinoma, gastric cancer, cholangiocarcinoma and the like. L'invention concerne un dérivé de pyrimido-pyridone en tant qu'inhibiteur de SOS1, son procédé de préparation et son utilisation. Le dérivé de pyrimido-pyridone a une structure telle que représentée dans la formule (I), et a des effets significatifs pour inhiber une voie de signalisation RAS et traiter et/ou prévenir des cancers. Les cancers comprennent le cancer du pancréas, le cancer colorectal, le cancer du poumon, le carcinome hépatocellulaire, le carcinome rénal, le cancer de l'estomac, le cholangiocarcinome et analogues. 一种作为SOS1抑制剂的嘧啶并吡啶酮类衍生物、其制备方法及用途。所述嘧啶并吡啶酮类衍生物的结