USE OF ASCORBIC ACID AS STABILIZING AGENT FOR ANTI B7-H3 ANTIBODIES

The present invention relates to pharmaceutical compositions comprising a radiolabeled B7H3 antibody or antigen binding fragment thereof and ascorbic acid, methods for stabilizing pharmaceutical compositions and use of ascorbic acid as a stabilizing agent and/or a scavenger agent. La présente invent...

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Bibliographische Detailangaben
Hauptverfasser:	JENSEN, Andreas Ingeman, TRUMP, David, LUND-HANSEN, Torben, NAGEL, Johannes, THOE FØRSTER, Jon, KRAMER, Beth
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to pharmaceutical compositions comprising a radiolabeled B7H3 antibody or antigen binding fragment thereof and ascorbic acid, methods for stabilizing pharmaceutical compositions and use of ascorbic acid as a stabilizing agent and/or a scavenger agent. La présente invention concerne des compositions pharmaceutiques comprenant un anticorps B7H3 radiomarqué ou un fragment de liaison à l'antigène de celui-ci et de l'acide ascorbique, des méthodes de stabilisation de compositions pharmaceutiques et l'utilisation de l'acide ascorbique en tant qu'agent stabilisant et/ou agent de piégeage.