METHODS FOR TRANSDUCING IMMUNE CELLS

Provided herein are improved methods for transducing immune cells, such as T cells, with retroviral vectors to express exogenous gene products, such as chimeric antigen receptors (CARs). Provided herein are methods that increase transduction efficiency thereby increasing the percentage of immune cel...

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Bibliographische Detailangaben
Hauptverfasser:	LUMAN, Todd, ZHANG, Chupei, HUANG, Tom Tao, RAO, Suma, GERMANSDERFER, Abraham, ZARAGOZA, Josergio, NI, Yajin
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are improved methods for transducing immune cells, such as T cells, with retroviral vectors to express exogenous gene products, such as chimeric antigen receptors (CARs). Provided herein are methods that increase transduction efficiency thereby increasing the percentage of immune cells in a population expressing the exogenous gene product. Associated cells, cell populations, compositions and methods of use are also provided. L'invention concerne des procédés améliorés de transduction de cellules immunitaires, telles que des lymphocytes T, comprenant des vecteurs rétroviraux pour exprimer des produits géniques exogènes, tels que des récepteurs d'antigènes chimériques (CAR). L'invention concerne des procédés qui augmentent l'efficacité de transduction, augmentant ainsi le pourcentage de cellules immunitaires dans une population exprimant le produit génique exogène. L'invention concerne également des cellules, des populations de cellules, des compositions et des procédés d'utilisation associés.