SHANZHUANG LIPID-LOWERING MICROPELLET AND PREPARATION METHOD THEREFOR

A Shanzhuang lipid-lowering micropellet and a preparation method therefor. The micropellet is prepared from the following raw materials in parts by weight: 1240 parts of semen cassiae, 620 parts of hawthorn, 420 parts of lotus leaves, 150-320 parts of dextrin, 20-36 parts of sucrose, 15-32 parts of...

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Hauptverfasser: WANG, Jia, LIU, Jingping, CHEN, Keling, LIU, Quanguo, LI, Dang
Format: Patent
Sprache:chi ; eng ; fre
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Zusammenfassung:A Shanzhuang lipid-lowering micropellet and a preparation method therefor. The micropellet is prepared from the following raw materials in parts by weight: 1240 parts of semen cassiae, 620 parts of hawthorn, 420 parts of lotus leaves, 150-320 parts of dextrin, 20-36 parts of sucrose, 15-32 parts of konjac glucomannan, and 18-25 parts of hydroxypropylmethyl cellulose. The prepared Shanzhuang lipid-lowering micropellet has a relatively high content of active ingredients, i.e. chrysophanol and aurantio-obtusin. The active ingredient of lotus leaves is nuciferine, which is an alkaloid, and lotus leaves are extracted separately from hawthorn so as to avoid possible reactions with an acid, thereby increasing active ingredients of the micropellet. Hawthorn is extracted with an ionic liquid, so that the flavonoid substances and the like in hawthorn can be completely extracted. The use of a micropellet dosage form can shorten the disintegration time of a drug in the human body, thereby improving the utilization rate o