THIAZOLOPYRIMIDONES AS INHIBITORS OF DDR1/2 AND THERAPEUTIC USES THEREOF

The present invention relates to a group of compounds of formula (I) which are inhibitors of the Discoidin Domain Receptors (DDR1/2), whose overexpression is produced in several diseases such as cancer, pulmonary fibrosis, cirrhotic liver, liver fibrosis, lupus nephritis, osteoarthritis, rheumatoid...

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Bibliographische Detailangaben
Hauptverfasser:	PASTOR FERNÁNDEZ, Joaquín, GARCÍA CAMPOS, Francisco Javier, CEBRIÁ GÓMEZ, Antonio, BLANCO-APARICIO, Carmen, MARTÍNEZ GONZÁLEZ, Sonia
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a group of compounds of formula (I) which are inhibitors of the Discoidin Domain Receptors (DDR1/2), whose overexpression is produced in several diseases such as cancer, pulmonary fibrosis, cirrhotic liver, liver fibrosis, lupus nephritis, osteoarthritis, rheumatoid arthritis and atherosclerosis, so the compounds of the invention are useful for the treatment of said diseases. La présente invention concerne un groupe de composés de formule (I) qui sont des inhibiteurs des récepteurs à domaine discoïdine (DDR1/2), dont la surexpression est produite dans plusieurs maladies telles que le cancer, la fibrose pulmonaire, le foie cirrhotique, la fibrose hépatique, la néphropathie lupique, l'arthrose, la polyarthrite rhumatoïde et l'athérosclérose, de sorte que les composés de l'invention sont utiles pour le traitement desdites maladies.