IMMUNOGENIC COMPOSITION COMPRISING MULTIVALENT STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES

The present invention relates to an immunogenic composition comprising multivalent Streptococcus pneumoniae polysaccharide-protein conjugates. Each conjugate comprises a capsular polysaccharide of a different Streptococcus pneumoniae serotype conjugated to a carrier protein. More specifically, the present invention includes a multivalent immunogenic composition in which each conjugate comprises a capsular polysaccharide derived from a different Streptococcus pneumoniae serotype conjugated to a carrier protein, wherein the capsular polysaccharide comprises a) a capsular polysaccharide of any one or more serotypes selected from the group consisting of serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F, and b) a capsular polysaccharide of any one or more serotypes selected from the group consisting of serotypes 10A, 11A, 12F, 15B, 22F, 23A and 35B. Compared to a conventional Prevenar13, the multivalent immunogenic composition according to the present invention can induce immune responses to more diverse serotypes. In particular, the conventional Prevenar13 was designed mainly for frequently occurring serotypes in Europe and North America, whereas the immunogenic composition according to the present invention has high coverage in Europe and North America, and all over Asia. Therefore, a multivalent immunogenic composition according to the present invention can be effectively used in preventing diseases caused by Streptococcus pneumoniae in infants, children and adults. La présente invention concerne une composition immunogène comprenant des conjugués de protéine-polysaccharide de Streptococcus pneumoniae. Chaque conjugué comprend un polysaccharide capsulaire d'un sérotype de Streptococcus pneumoniae différent conjugué à une protéine porteuse. Plus spécifiquement, la présente invention comprend une composition immunogène multivalente dans laquelle chaque conjugué comprend un polysaccharide capsulaire issu d'un sérotype de Streptococcus pneumoniae différent conjugué à une protéine porteuse, le polysaccharide capsulaire comprenant : a) un polysaccharide capsulaire d'un ou de plusieurs sérotypes choisis dans le groupe constitué par les sérotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F et 23F et b) un polysaccharide capsulaire d'un ou de plusieurs sérotypes choisis dans le groupe constitué par les sérotypes 10A, 11A, 12F, 15B, 22F, 23A et 35B. Par comparaison avec une Prevenar 13 classique, la composition immunogène multivalente de la présente in