COCHLEAR OUTER HAIR CELL REGENERATED BY ECTOPIC JOINT OVEREXPRESSION OF ATOH1 AND IKZF2 AND APPLICATION THEREOF

The present invention provides a cochlear outer hair cell (OHC) regenerated by ectopic joint overexpression of Atoh1 and Ikzf2 and an application thereof. Specifically, the present invention provides an active ingredient combination capable of being used for regenerating a cochlear OHC, and a use th...

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Bibliographische Detailangaben
Hauptverfasser:	LIU, Zhiyong, REN, Minhui, LUO, Zhengnan, LI, Shuting, WANG, Guangqin, SUN, Suhong, HE, Shunji
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a cochlear outer hair cell (OHC) regenerated by ectopic joint overexpression of Atoh1 and Ikzf2 and an application thereof. Specifically, the present invention provides an active ingredient combination capable of being used for regenerating a cochlear OHC, and a use thereof. The active ingredient combination comprises an Ikzf2 protein and an Atoh1 protein; and after the active ingredient combination is administered to a subject suffering from hearing impairment related to cochlear OHC degeneration and/or injury, hearing impairment can be alleviated by regenerating an OHC-like cell. A new method is provided for clinical treatment of hearing impairment. La présente invention concerne une cellule ciliée externe (OHC) cochléaire régénérée par surexpression conjointe ectopique d'Atoh1 et d'Ikzf2 et une application associée. Plus précisément, la présente invention concerne une combinaison de principes actifs capable d'être utilisée pour régénérer une OHC cochléaire, et une utilisation