ATP-PRT VARIANT WITH REDUCED FEEDBACK INHIBITION BY HISTIDINE, AND HISTIDINE-PRODUCING STRAIN EXPRESSING SAME

The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant with reduced feedback inhibition by histidine, and a strain expressing same, the present invention maintaining activity even in a high concentration of histidine and thus enabling increased histidine produ...

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Hauptverfasser:	JO, Young Il, HAN, Jong Yun, KIM, Yong Soo, YANG, Chel Min
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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creator	JO, Young Il HAN, Jong Yun KIM, Yong Soo YANG, Chel Min
description	The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant with reduced feedback inhibition by histidine, and a strain expressing same, the present invention maintaining activity even in a high concentration of histidine and thus enabling increased histidine production. La présente invention concerne un variant d'ATP-phosphoribosyltransférase dérivé de l'hisG de E. coli présentant une rétro-inhibition réduite par l'histidine, et une souche l'exprimant, la présente invention maintenant l'activité même dans une concentration élevée d'histidine et permettant ainsi une production accrue d'histidine. 본 발명은 히스티딘에 의한 피드백 억제가 감소된 대장균 hisG 유래 ATP-포스포리보실전이효소의 변이체 및 이를 발현하는 균주에 대한 것으로, 높은 히스티딘 농도에서도 활성을 유지하므로 히스티딘 생산을 증가시킬 수 있다.
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subjects	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
title	ATP-PRT VARIANT WITH REDUCED FEEDBACK INHIBITION BY HISTIDINE, AND HISTIDINE-PRODUCING STRAIN EXPRESSING SAME
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