ATP-PRT VARIANT WITH REDUCED FEEDBACK INHIBITION BY HISTIDINE, AND HISTIDINE-PRODUCING STRAIN EXPRESSING SAME

ATP-PRT VARIANT WITH REDUCED FEEDBACK INHIBITION BY HISTIDINE, AND HISTIDINE-PRODUCING STRAIN EXPRESSING SAME

The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant with reduced feedback inhibition by histidine, and a strain expressing same, the present invention maintaining activity even in a high concentration of histidine and thus enabling increased histidine produ...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JO, Young Il, HAN, Jong Yun, KIM, Yong Soo, YANG, Chel Min
Format: Patent
Sprache:eng ; fre ; kor
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant with reduced feedback inhibition by histidine, and a strain expressing same, the present invention maintaining activity even in a high concentration of histidine and thus enabling increased histidine production. La présente invention concerne un variant d'ATP-phosphoribosyltransférase dérivé de l'hisG de E. coli présentant une rétro-inhibition réduite par l'histidine, et une souche l'exprimant, la présente invention maintenant l'activité même dans une concentration élevée d'histidine et permettant ainsi une production accrue d'histidine. 본 발명은 히스티딘에 의한 피드백 억제가 감소된 대장균 hisG 유래 ATP-포스포리보실전이효소의 변이체 및 이를 발현하는 균주에 대한 것으로, 높은 히스티딘 농도에서도 활성을 유지하므로 히스티딘 생산을 증가시킬 수 있다.