P21 MRNA TARGET AREAS FOR SILENCING

Compositions of matter comprising RNA silencing molecules capable of mediating cleavage of p21 mRNA are disclosed. Methods of eradicating senescent cells or cancer cells, as well as methods of treating senescence-associated diseases or disorders, cancer, and fibrotic diseases and disorders are also...

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Bibliographische Detailangaben
Hauptverfasser:	RAICHLIN, Dina, KATZ-KADOSH, Etti, BARKEY, Shirin, PILPEL, Noam, KNANY, Alaa, BOROVSKY, Noam, SHAPIRO, Anastasia, OVADYA, Yossi, GILLIS, Ella, COHEN, Noam, KRIEGER, Gat, BACHELET, Ido
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Compositions of matter comprising RNA silencing molecules capable of mediating cleavage of p21 mRNA are disclosed. Methods of eradicating senescent cells or cancer cells, as well as methods of treating senescence-associated diseases or disorders, cancer, and fibrotic diseases and disorders are also disclosed. L'invention concerne des compositions de matière qui comprennent des molécules de silençage d'ARN pouvant assurer la médication du capables de médier le clivage de l'ARNm p21. L'invention concerne également des méthodes pour éradiquer des cellules sénescentes ou des cellules cancéreuses, ainsi que des méthodes pour traiter des maladies ou des troubles associés à la sénescence, le cancer, et des maladies et des troubles fibrotiques.