EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STROMAL CELLS GENETICALLY MODIFIED TO OVEREXPRESS HIF-1A AND HTERT

The present invention refers to extracellular vesicles (EVs) isolated from mesenchymal stromal cells genetically modified to overexpress HIF-1α and hTERT (MSCs-T- HIF). The present invention also refers to the method for obtaining the extracellular vesicles. Finally, the clinical applications of the...

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Hauptverfasser:	GÓMEZ FERRER, Marta, DORRONSORO GONZÁLEZ, Akaitz, SEPÚLVEDA SANCHIS, Pilar
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention refers to extracellular vesicles (EVs) isolated from mesenchymal stromal cells genetically modified to overexpress HIF-1α and hTERT (MSCs-T- HIF). The present invention also refers to the method for obtaining the extracellular vesicles. Finally, the clinical applications of the EVs in cellular therapy, in particular for the treatment of autoimmune diseases and ischemic diseases are also contemplated. La présente invention concerne des vésicules extracellulaires (EV) isolées à partir de cellules stromales mésenchymateuses génétiquement modifiées pour surexprimer HIF-1α et hTERT (MSC-T-HIF). La présente invention concerne également le procédé d'obtention desdites vésicules extracellulaires. Enfin, l'invention concerne également les applications cliniques desdites EV en thérapie cellulaire, en particulier pour le traitement de maladies auto-immunes et de maladies ischémiques.