NOVEL PEPTIDE CAPABLE OF INHIBITING TGF-β SIGNALING AND USE THEREOF

The present invention relates to a novel peptide capable of inhibiting TGF-β signaling and a use thereof. With ability to inhibit the TGF-β-induced signaling pathway or the expression of TGF-β, the peptide of the present invention can treat or prevent various diseases caused by TGF-β signaling and f...

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Bibliographische Detailangaben
Hauptverfasser: GO, Ga-Yeon, YUK, Chae-Min, SHIN, Sang-Chul, JANG, Mi-Hue, LEE, Young-Eun
Format: Patent
Sprache:eng ; fre ; kor
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Zusammenfassung:The present invention relates to a novel peptide capable of inhibiting TGF-β signaling and a use thereof. With ability to inhibit the TGF-β-induced signaling pathway or the expression of TGF-β, the peptide of the present invention can treat or prevent various diseases caused by TGF-β signaling and furthermore can effectively inhibit the TGF-β signaling-induced tumorigenesis such as tumor growth and metastasis. La présente invention concerne un nouveau peptide pouvant inhiber la signalisation du TGF-β et son utilisation. Le peptide selon la présente invention a la capacité d'inhiber la voie de signalisation induite par TGF-β ou l'expression de TGF-β, peut traiter ou prévenir diverses maladies provoquées par la signalisation du TGF-β et peut en outre inhiber de manière efficace la tumorigenèse induite par la signalisation du TGF-β, telle qu'une croissance tumorale et une métastase. 본 발명은 TGF-β 신호전달을 억제할 수 있는 신규한 펩타이드 및 이의 용도에 관한 것이다. 본 발명의 펩타이드는 TGF-β에 의한 신호전달 경로를 억제하거나 또는 TGF-β의 발현을 억제할 수 있는 바, TGF-β 신호전달에 의한 다양한 질환을 치료 또는 예방할 수 있고, 나아가서는 TGF-β 신호전달에 의해 유도되는 종양 성장 및 전의 등의 암화 과정을 효과적으로 저해할 수 있다.