A HEMOSTATIC TISSUE ADHESIVE COMPOSITION COMPRISING AN NCO-TERMINATED URETHANE PREPROLYMER

The invention relates to a NCO-terminated urethane preprolymer based on at least a polyol oligomer and a diisocyanate, wherein the polyol oligomer is polyhydroxyalkanoate-diol oligomers (oligoPHA- diol) having a hydroxyl value of more than or equal to 149 mgKOH/g, and the diisocyanate is selected fr...

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Bibliographische Detailangaben
Hauptverfasser:	VIDAL, Valerie, AVEROUS, Luc, WENDELS, Sophie
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE ADHESIVES CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON DISINFECTION, STERILISATION, OR DEODORISATION OF AIR DYES HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS NATURAL RESINS NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL ORGANIC MACROMOLECULAR COMPOUNDS PAINTS POLISHES THEIR PREPARATION OR CHEMICAL WORKING-UP USE OF MATERIALS AS ADHESIVES
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Beschreibung
Zusammenfassung:	The invention relates to a NCO-terminated urethane preprolymer based on at least a polyol oligomer and a diisocyanate, wherein the polyol oligomer is polyhydroxyalkanoate-diol oligomers (oligoPHA- diol) having a hydroxyl value of more than or equal to 149 mgKOH/g, and the diisocyanate is selected from the list consisting of 1,4- butane diisocyanate (BDI), hexamethylene diisocyanate (6-HDI), dimeryl diisocyanate (DDI), pentamethylene diisocyanate (PDI), L-lysine diisocyanate (LDI), 1,7- heptamethylene diisocyanate (7-HDI), and mixtures thereof. The invention also relates to a method for preparing such a NCO-terminated urethane prepolymer and for a method for preparing polyhydroxyalkanoate-diol oligomers (oligoPHA-diol). The invention also relates to a hemostatic tissue adhesive composition and a hemostatic tissue adhesive. The invention also relates to a kit for the preparation of a hemostatic tissue adhesive. L'invention concerne un prépolymère d'uréthane à terminaisons NCO à base d'au moins un oligomère polyol et d'un diisocyanate, l'oligomère polyol étant des oligomères polyhydroxyalcanoate-diol (oligoPHA-diol) ayant une valeur hydroxyle supérieure ou égale à 149 mgKOH/g, et le diisocyanate étant choisi dans la liste consistant en 1,4-butanediisocyanate (BDI), hexaméthylène diisocyanate (6-HDI), dimeryldiisocyanate (DDI), pentaméthylène diisocyanate (PDI), L-lysine-diisocyanate (LDI), 1,7-heptaméthylène diisocyanate (7-HDI), et leurs mélanges. L'invention concerne également un procédé de préparation d'un tel prépolymère d'uréthane à terminaisons NCO et un procédé de préparation d'oligomères polyhydroxyalcanoate-diol (oligoPHA-diol). L'invention concerne également une composition d'adhésif tissulaire hémostatique et un adhésif tissulaire hémostatique. L'invention concerne en outre un kit pour la préparation d'un adhésif tissulaire hémostatique.