BIOMARKER FOR PREOPERATIVE IDENTIFICATION OF BENIGN AND MALIGNANT THYROID NODULES, AND KIT AND APPLICATION THEREOF

Involved are a biomarker for preoperative identification of benign and malignant thyroid nodules, and a kit and an application thereof. The level of 17 metabolites in the peripheral blood plasma of a thyroid nodule patient is measured by means of metabolomics analysis, and by combining omics analysis and a machine learning method, a diagnosis model is constructed and a receiver operating curve (ROC) is used to evaluate the thyroid cancer diagnosis efficacy. The area of a metabolic marker combination diagnosis model consisting of the foregoing metabolites under the ROC in thyroid nodule diagnosis can reach 95.05%, and the sensitivity and the specificity both are higher than 88%, and therefore, the model can be applied to the identification of the benign and malignant thyroid nodules. L'invention concerne un biomarqueur d'identification préopératoire de nodules thyroïdiens bénins et malins, et ses kit et application. Le niveau de 17 métabolites dans le plasma sanguin périphérique d'un patient atteint d'un nodul