ANTISENSE OLIGONUCLEOTIDES TARGETING FOXG1

Provided herein are compositions and methods for treating and/or ameliorating FOXG1 syndrome or the symptoms associated therewith. The compositions and methods disclosed herein utilize antisense oligonucleotides that target FOXG1 in order to modulate FOXG1 by, for example, increasing the amount of F...

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Bibliographische Detailangaben
Hauptverfasser:	REICH, Scott, GEICK, Anke, VORNLOCHER, Hans-Peter
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	Provided herein are compositions and methods for treating and/or ameliorating FOXG1 syndrome or the symptoms associated therewith. The compositions and methods disclosed herein utilize antisense oligonucleotides that target FOXG1 in order to modulate FOXG1 by, for example, increasing the amount of FOXG1 (e.g. mRNA encoding a FOXG1 protein or FOXG1 protein) in a cell, thereby restoring FOXG1 function. L'invention concerne des compositions et des méthodes pour traiter et/ou atténuer le syndrome de FOXG1 ou les symptômes associés à celui-ci. Les compositions et les méthodes de l'invention utilisent des oligonucléotides antisens ciblant FOXG1 afin de moduler FOXG1, par exemple, par augmentation de la quantité de FOXG1 (par exemple l'ARNm codant pour une protéine FOXG1 ou une protéine FOXG1) dans une cellule, ce qui permet de restaurer la fonction FOXG1.